Journal article
Pregnancy, antiseizure medications and unexplained intrauterine foetal death
Frank JE Vajda, Terence J O'Brien, Janet E Graham, Alison E Hitchcock, Piero Perucca, Cecilie M Lander, Mervyn J Eadie
Epilepsy and Behavior | Elsevier | Published : 2024
Abstract
Objective: To assess the role of antiseizure medication (ASM) regimens and other factors in relation to the occurrence of intrauterine foetal death (IUFD) in pregnant women with epilepsy (WWE) enrolled in the Raoul Wallenberg Australian Pregnancy Register of Antiepileptic Drugs (APR). Results: IUFDs occurred in 70 (3.01 %) of 2,323 prospective pregnancies from WWE with known outcomes in the APR. Factors associated with IUFD occurrence included older maternal age, enrolment in the APR at an earlier stage of pregnancy, history of pregnancies which did not result in livebirths, parental history of foetal malformations, and maternal use of carbamazepine, lamotrigine or ethosuximide. Individual A..
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Funding Acknowledgements
We are grateful to professional and lay colleagues and to various lay bodies for referring patients to the Raoul Wallenberg Australian Pregnancy Register of Antiepileptic Drugs, and to the Scientific Advisory Board and the Ethical Research Committees of St. Vincent's Hospital, Monash Medical Centre, the Royal Melbourne Hospital and other institutions for their successive ethics oversight of the APR. The Epilepsy Society of Australia, Epilepsy Action Australia, the Royal Melbourne Hospital Neuroscience Foundation, the NHMRC, and the pharmaceutical companies Sanofi-Aventis, UCB Pharma, Janssen-Cilag, Novartis, SciGen, Eisai, and Genzyme have provided financial support towards maintaining the APR at various stages of its existence.